"Prince Fahnbulleh, aged 24, is wanted on an outstanding arrest warrant for murder," NSW Police said in a statement on Sunday.
Emergency crews were called to a home at St Clair about 4.30pm on Friday where they found an unconscious man with serious injuries.
The injured man was given aid by police until paramedics arrived, however he was unable to be saved and died at the scene.
Mr Fahnbulleh came to the home and argued with the victim before stabbing him and fleeing, police say.
Two females at the home at the time of the incident were not physically injured but were assessed by paramedics.
Police searched for Mr Fahnbulleh following the incident and say he may have been armed and travelling on a dirt bike.
Investigators have called for public assistance to locate Mr Fahnbulleh. He is described as being of African appearance, about 165cm tall, with a solid build, brown eyes, black hair and a beard.
He is known to visit the Blacktown, Seven Hills, Doonside, Mount Druitt and St Marys areas.
Anyone who sees Mr Fahnbulleh, or knows where he is, should not approach him and instead contact triple-zero.
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