The 21-count indictment unsealed on Thursday in Nevada's Clark County District Court, which includes Las Vegas, again charges the 48-year-old with sexual assault, lewdness and kidnapping.
It also adds felony charges of producing and possessing child sexual abuse materials.
It comes after the Nevada Supreme Court in September ordered the dismissal of Chasing Horse's original indictment, while leaving open the possibility for charges to be refiled.
The court sided with Chasing Horse, saying in its scathing order that prosecutors had abused the grand jury process.
Clark County District Attorney Steve Wolfson quickly vowed to seek another indictment.
The initial 18-count indictment charged Chasing Horse with more than a dozen felonies. He had pleaded not guilty.
His lawyer, Kristy Holston, had also argued the case should be dismissed because, the former actor said, the sexual encounters were consensual.
One of his accusers was younger than 16, the age of consent in Nevada, when the abuse began, according to the indictment.
Neither Wolfson nor Holston immediately responded Thursday to phone or emailed requests for comment.
Best known for portraying the character Smiles A Lot in the 1990 movie Dances with Wolves, Chasing Horse was born on the Rosebud Reservation in South Dakota, which is home to the Sicangu Sioux, one of the seven tribes of the Lakota nation.
After starring in the Oscar-winning film, authorities have said, he propped himself up as a self-proclaimed Lakota medicine man while travelling around North America to perform healing ceremonies.
He is accused of using that position to gain the trust of vulnerable Indigenous women and girls, lead a cult and take underage wives.
Chasing Horse's arrest in January reverberated around Indian Country and helped law enforcement in the US and Canada corroborate long-standing allegations against him, leading to more criminal charges.
He has remained jailed in Las Vegas since his arrest.
