India won the toss and elected to bowl, with the temperature expected to nudge 40C in Perth on Wednesday.
Australia lead the series 2-0 following easy wins in Queensland.
Newcomer Georgia Voll starred in those two games, scoring 46 not out on debut before following it up with 101.
Her hot run of form resulted in her being added for Australia's upcoming three-match ODI tour of New Zealand.
Australia posted a whopping 8-371 in the second ODI against India, with Voll's maiden century complemented by a ton from player of the match Ellyse Perry (105 off 75 balls).
India have entered the clash in Perth without opener Priya Punia, who was ruled out with a knee injury.
Priya Mishra was their only other change, with Arundhati Reddy and Titas Sadhu coming into the XI.
AUSTRALIA: Georgia Voll, Phoebe Litchfield, Ellyse Perry, Beth Mooney, Annabel Sutherland, Ashleigh Gardner, Tahlia McGrath (capt), Sophie Molineux, Alana King, Kim Garth, Megan Schutt.
INDIA: Smriti Mandhana, Harleen Deol, Harmanpreet Kaur (capt), Jemimah Rodrigues, Richa Ghosh, Deepti Sharma, Minnu Mani, Saima Thakor, Arundhati Reddy, Titas Sadhu, Renuka Singh.
23°C