Mr Miles will be sworn in on Friday after Annastacia Palaszczuk tenders her resignation to Queensland Governor Jeannette Young in Brisbane.
Mr Miles will be joined by new deputy Cameron Dick, marking the first time since 2005 the Queensland Labor Party will have two men at the helm.
Mr Miles is set to hit the ground running in his new role, with a 2pm AEST press conference planned to detail his priorities.
The cost of living, housing, education and youth crime are expected to be high on the agenda with reports he will also announce new emission reduction targets.
The incoming premier has already confirmed an independent authority will be established to review 2032 Brisbane Olympic infrastructure plans, with the controversial $2.7 billion Gabba rebuild on the list.
Mr Miles emerged as the frontrunner to take over the top job soon after Ms Palaszczuk's shock announcement on Sunday.
An emotional Ms Palaszczuk stepped down after almost nine years as premier, quickly endorsing Mr Miles as her successor.
However he faced opposition with Health Minister Shannon Fentiman announcing a leadership tilt.
Barely 12 hours later Ms Fentiman withdrew her bid, saying it was clear Mr Miles had the numbers to become premier amid speculation of a backroom union deal.
Mr Miles will start Friday with a 10am Labor caucus meeting from where he's set to emerge as the new leader with Mr Dick by his side.
They will be sworn in after lunch at Queensland Government House.
A new-look cabinet is set to be unveiled on Monday.
Mr Miles has already confirmed Mr Dick will remain as treasurer and also step up as deputy premier, with Ms Fentiman to retain the health portfolio.
Annastacia Palaszczuk shocked colleagues when she announced she would resign as premier. (Jono Searle/AAP PHOTOS)
"Steven Miles has the support to go ahead as the premier and I know he is going to do an excellent job," employment minister Di Farmer said.
Mr Dick said on Thursday the caucus would endorse the leadership team and discuss "two vacancies".
Transport minister Mark Bailey said he would step aside to make way for new blood.
Tourism minister Stirling Hinchliffe did not expect a cabinet position because he is due to retire before the October 2024 poll.
Mr Dick did not rule out Ms Palaszczuk attending the caucus meeting.
"She is more than welcome by all members of the caucus given her outstanding service to our state and our party," he said.
Ms Farmer said Ms Palaszczuk would be revered as the person who steered Queensland through the COVID-19 crisis.
"She stood up and ensured Queenslanders felt safe," she said.
Big shoes await Mr Miles.
Ms Palaszczuk was Australia's longest-serving sitting premier, enjoying 12 years as party leader.
She went from an opposition with seven seats to becoming premier in 2015, going on to become the first woman to lead a party to three state election victories.
Ms Palaszczuk will also depart her Inala seat by year's end, prompting a by-election.
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