Ukrainian defences have on Friday shot down 81 missiles, including 11 cruise missiles that were intercepted by F-16 warplanes provided by Western allies earlier in 2024, Mr Zelenskiy said.
Russia is "terrorising millions of people" with such assaults, he said on his Telegram channel, renewing his plea for international unity against Russian President Vladimir Putin.
"A strong reaction from the world is needed: a massive strike - a massive reaction. This is the only way to stop terror," Mr Zelenskiy said.
Volodymyr Zelenskiy says Russia is terrorising millions of people and a massive response is needed. (AP PHOTO)
But uncertainty surrounds how the war might unfold in 2025. President-elect Donald Trump, who takes office in January, has vowed to end the war and thrown into doubt whether vital US military support for Kyiv will continue.
The US Embassy in Kyiv said Friday's attack also targeted transport networks and other key facilities.
Russia has repeatedly attempted to cripple Ukraine's electricity system in an effort to break the will of civilians left in the dark with no running water or heating and to disrupt Ukrainian defence manufacturing.
Ukrainian Energy Minister Herman Halushchenko said energy workers were doing everything necessary to "minimise negative consequences for the energy system", promising to release more details on damages once the security situation allowed it.
Ukraine's air force reported multiple strike drones launched at Ukraine overnight followed by swarms of cruise missiles in the country's air space. It said Russia also used air-launched ballistic Kinzhal missiles against Ukraine's western regions.
Moscow has declared the aerial attacks are aimed at hobbling Ukraine's defence industry, thwarting the production of missiles, drones, armoured vehicles and artillery, among other weapons.
A similar massive attack on November 28 involved about 200 missiles and drones and left more than a million households without power until emergency teams restored supplies.
Ukrainian officials have warned that Russia is stockpiling cruise and ballistic missiles for more attacks.
On November 21, Russia for the first time used an intermediate range, hypersonic, ballistic missile to strike an industrial plant in the city of Dnipro, in eastern Ukraine.
About half of Ukraine's energy infrastructure has been destroyed during the war with Russia. (AP PHOTO)
Mr Putin described the attack with the Oreshnik missile as retaliation for Ukrainian strikes on Russian territory with longer-range Western weapons.
He declared that more attacks with the new weapon could follow, and US officials warned on Wednesday that the Oreshnik could be used again in coming days. There was no immediate sign one was launched in Friday's attack.
On Wednesday, the Russian defence ministry said Ukraine struck an air base in Taganrog in the southern Rostov region with six US-supplied ATACMS missiles, injuring several soldiers and damaging buildings and a few vehicles. It vowed to strike back.
About half of Ukraine's energy infrastructure has been destroyed during the almost three years of war with Russia, and rolling electricity blackouts are widespread.
Kyiv's Western allies have provided Ukraine with air defence systems to help it protect critical infrastructure, but Russia has sought to overwhelm the air defences with combined strikes involving big numbers of missiles and drones.
Russia has held the initiative in 2024 as its military has steadily rammed through Ukrainian defences in the east in a series of slow but steady offensives.
